Results
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| Property | Organism | Value | Units | ID | Details |
|---|---|---|---|---|---|
| Number of DNA damage events caused by oxidative damage | Human Homo sapiens | ≤1000 | bases damaged per cell per day | 100383 | R. Weinberg, The Biology... |
| Number of DNA damage events caused by oxidative damage | Rat Rattus norvegicus | 10000 | bases damaged per cell per day | 100415 | R. Weinberg, The Biology... |
| Rate of DNA base damage events | Unspecified | >10,000 | Events/cell/day | 106953 | Jacobs AL, Schär P. DNA... |
| Ratio between amount of damage due to reactive oxygen species between mitochondrial DNA and nuclear DNA | Unspecified | 10 | Unitless | 103277 | Turunen M, Olsson J,... |
| Relative amount of secreted oxidized DNA bases (likely a reporter for organism wide DNA damage repair) between mouse and humans | Human Homo sapiens | 18 | fold difference | 105255 | Adelman R, Saul RL, Ames... |
| Oxidative damages to DNA | Mammals | rat ~10^5: human ~10^4 | oxidative hits/cell/day | 112974 | Ames BN, Shigenaga MK... |
| Estimated numbers of single-strand breaks and spontaneous base losses in nuclear DNA | Eukaryotes | single-strand breaks and spontaneous base losses ≤10^4: with other types of damage ~10^5 | DNA damages/cell/day | 112970 | Hoeijmakers JH. DNA damage... |
| Endogenous DNA damages in mammalian cells | Mammals | Table - link | DNA damages/cell/day | 107472 | Editor: Dr. Robert A. Meyers... |
| Number of DNA depurinations | Human Homo sapiens | 2,000-10,000 | depurinations/cell/day | 112975 | Lindahl T. Instability... |
| Potentially mutagenic lesions in DNA | Mammals | ~20,000 | lesions/diploid cell/day | 112657 | Preston BD, Albertson TM... |
| Rate of production of single-strand breaks (SSBs) and apurinic/apyrimidinic (AP) sites and oxidation products 8-oxoguanine (8-oxoG) and thymine glycol (TG) in DNA | Unspecified | SSBs and AP sites in vivo ≈600 per h: 8-oxoG ≥≈200/cell/hour: TG ≥100/cell/hour | N/A | 112979 | Vilenchik MM, Knudson... |
| Half-time of DNA repair of single-strand breaks (SSB) and double-strand breaks (DSB) | Human Homo sapiens | SSB a few minutes: DSB >1 hour | N/A | 112195 | Collins AR, Ma AG, Duthie... |
| Half-life of an individual cytosine residue in single-stranded DNA in solution at 37˚C and pH 7.4 | Unspecified | ~200 | years | 112976 | Lindahl T. Instability... |
| Ratio between deamination rates of cytosine on single stranded and double stranded DNA | Mammals | >=100 | Fold | 102465 | Barnes DE, Lindahl T.Repair... |
| Number of DNA pol IV | Bacteria Escherichia coli | ~200 | Molecules/cell | 108718 | Hastings PJ et al., ... |
| Abundance of DNA gyrase | Bacteria Mycoplasma pneumoniae | 50 | A2B2 tetramers/cell | 108352 | Maier T, Schmidt A, Güell M... |
| Number of spontaneous lesions that occur in DNA within 24 h as a result of deamination, depurinization, oxidation, and incorrect methylation | Human Homo sapiens | 100000 | Lesions/day | 106789 | Krutyakov VM, Kravetskaya... |
| The rate constant for Fe–S cluster damage by O2− (superoxide) in dehydratase and O2- concentration in wildtype | Bacteria Escherichia coli | kcat/Km ≤5×10^6M^−1×s^−1: O2− concentration in wildtype cell 10^−10M | N/A | 112963 | Imlay JA. The molecular... |
| Number of ATP molecules that may be required for repair of a single double-strand break (used in signaling, the generation of repair foci, and the formation of the RAD51 nucleofilament) | Unspecified | >10^4 | ATP molecules | 112972 | Hoeijmakers JH. DNA damage... |
| Comparison of values for calf thymus DNA density from the literature | Cow Bos Taurus | ~1.7 Table - link | g/cm^3 | 112350 | Śmiałek MA, Jones NC... |