Statistically enhanced promiscuity of structurally correlated patterns

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Feb;77(2 Pt 1):020901. doi: 10.1103/PhysRevE.77.020901. Epub 2008 Feb 1.

Abstract

We predict that patterns with correlated surface density of atoms have statistically higher promiscuity (ability to bind stronger to an arbitrary pattern) as compared with noncorrelated patterns with the same average surface density. We suggest that this constitutes a generic design principle for highly connected proteins (hubs) in protein interaction networks. We develop an analytical theory for this effect. We show that our key predictions are generic and independent, qualitatively, on the specific form of the interatomic interaction potential, provided it has a finite range.

MeSH terms

  • Computer Simulation
  • Models, Chemical*
  • Models, Statistical*
  • Protein Binding
  • Protein Interaction Mapping / methods*
  • Proteins / chemistry*
  • Statistics as Topic

Substances

  • Proteins