Number of mitochondrial DNA molecules in cell

Range >6,000 human HeLa cell: >1,000 mouse L cell Copies/cell
Organism Mammals
Reference Clayton DA. Replication of animal mitochondrial DNA. Cell. 1982 Apr 28 (4):693-705 p.693 right column 1st paragraphPubMed ID6178513
Primary Source Nass MM. Mitochondrial DNA. I. Intramitochondrial distribution and structural relations of single- and double-length circular DNA. J Mol Biol. 1969 Jun 28 42(3):521-8. AND Bogenhagen D, Clayton DA. The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid. J Biol Chem. 1974 Dec 25 249(24):7991-5.PubMed ID5816965, 4473454
Comments See values of 8,800 and 1,100±250 genomes per HeLa and Mouse L cell, respectively, in p.7993 table 1 in 2nd primary source. Note that hundreds of mitochondria may be present in a cell. See BNID 102919, 102918, 103062, 103063, 103064, 103065, 103066
Entered by Uri M
ID 105937