Movement of mitochondria in neuronal axons (see comments section)

Range stationary or bidirectionally ~60%: anterogradely or retrogradely ~40% %
Organism Eukaryotes
Reference Fu MM, Holzbaur EL. Integrated regulation of motor-driven organelle transport by scaffolding proteins. Trends Cell Biol. 2014 Oct24(10):564-74. doi: 10.1016/j.tcb.2014.05.002. p.566 right column bottom paragraphPubMed ID24953741
Primary Source [31] A.F. MacAskill, et al. Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses Eur. J. Neurosci., 32 (2010), pp. 231–240 doi: 10.1111/j.1460-9568.2010.07345.x. [32] T. Misgeld, et al. Imaging axonal transport of mitochondria in vivo Nat. Methods, 4 (2007), pp. 559–561 [33] L.G. Bilsland, et al. Deficits in axonal transport precede ALS symptoms in vivo Proc. Natl. Acad. Sci. U.S.A., 107 (2010), pp. 20523–20528 doi: 10.1073/pnas.1006869107.PubMed ID20946113, 17558414, 21059924
Comments P.565 left column 2nd paragraph:"In neuronal axons, the majority of mitochondria (∼60%) are either stationary or move bidirectionally with frequent directional changes, whereas the remainder move robustly in either the anterograde or retrograde directions [primary sources]." Primary sources [32, 33] studied mice.
Entered by Uri M
ID 112210