Number of accessory proteins involved in ribosome assembly

Range ≥300 accessory proteins
Organism Eukaryotes
Reference Doherty MK, Hammond DE, Clague MJ, Gaskell SJ, Beynon RJ. Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC. J Proteome Res. 2009 Jan8(1):104-12. doi: 10.1021/pr800641v. P.109 right column 2nd paragraphPubMed ID18954100
Primary Source [43] Fromont-Racine M, Senger B, Saveanu C, Fasiolo F. Ribosome assembly in eukaryotes. Gene. 2003 Aug 14 313: 17-42. Review. [44] Henras AK et al., The post-transcriptional steps of eukaryotic ribosome biogenesis. Cell Mol Life Sci. 2008 Aug65(15):2334-59. doi: 10.1007/s00018-008-8027-0. [45] Lebreton A et al., 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes, Nucleic Acids Res. 2008 Sep36(15):4988-99. doi: 10.1093/nar/gkn469.PubMed ID12957375, 18408888, 18658244
Comments P.109 right column 2nd paragraph:"The assembly of bacterial ribosomes is sequential and highly regulated (ref 42). Eukaryotic ribosome assembly, also sequential, is known to involve at least 300 accessory proteins (primary sources). Although the dynamics of the intact 40S and 60S subunits have been examined,(primary source 45, ref 46) there is no data describing the degradation rate of the individual subunits." See BNID 110025
Entered by Uri M
ID 112255