Half life of ubiquitin

Value 9 Hours
Organism Chinese hamster ovary (CHO)
Reference Carlson N, Rechsteiner M. Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions. J Cell Biol. 1987 Mar104(3):537-46. p.541 right column 2nd paragraphPubMed ID3029141
Primary Source Wu RS, Kohn KW, Bonner WM. Metabolism of ubiquitinated histones. J Biol Chem. 1981 Jun 10 256(11):5916-20.PubMed ID6263895
Method Pulse chase experiments
Comments From pulse-chase experiments, Wu et al. (primary source) reported that native ubiquitin is lost from Chinese hamster ovary cells with a half-life of 9 h.
Entered by Uri M
ID 106196