Fraction of Alzheimer's disease (AD) cases that are due to genetic mutations responsible for abnormal Amyloid-beta (Aβ) elevation and deposition in the brain
| Range | ~5 % |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Lauretti E, Iuliano L, Praticò D. Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy. Ann Clin Transl Neurol. 2017 Jun 21 4(8):564-574. doi: 10.1002/acn3.431 p.564 left columnPubMed ID28812046 |
| Comments | P.564 left column: "Only approximately 5% of the total AD cases are due to genetic mutations responsible for abnormal Amyloid-beta (Aβ) elevation and deposition in the brain. However, the etiology for the sporadic form of AD accounting for 95% of the remaining cases is still unknown, and so far no effective therapy is available [ref 2]. As result, in recent years the AD research field has moved more and more toward prevention and away from treatment." |
| Entered by | Uri M |
| ID | 114384 |