| Value |
16.5
years
|
| Organism |
Human Homo sapiens |
| Reference |
Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396. abstractPubMed ID22914163
|
| Method |
"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage." |
| Comments |
"Most notably, the diversity in mutation rate of single nucleotide polymorphisms is dominated by the age of the father at conception of the child. The effect is an increase of about two mutations per year. An exponential model estimates paternal mutations doubling every 16.5?years." |
| Entered by |
Uri M |
| ID |
110291 |