Conformation change upon formation of large interfaces (of proteins)

Range Table - link
Organism Unspecified
Reference Lo Conte L, Chothia C, Janin J. The atomic structure of protein-protein recognition sites. J Mol Biol. 1999 Feb 5 285(5):2177-98. p.2181 table 2PubMed ID9925793
Method Researchers performed an analysis of the atomic structure of the recognition sites seen in 75 protein-protein complexes of known three-dimensional structure
Comments The formation of complexes that have large interfaces is seen to involve large changes in conformation in those cases where native structures are available. These changes are generally described in publications reporting the X-ray structure of the complexes. They are summarised in Table 2 for the 20 complexes that have B>2000 Å^2. B=interface area
Entered by Uri M
ID 107914