Influence of exercise and of epinephrine on the total blood granulocyte pool (TBGP), circulating granulocyte pool (CGP), marginal granulocyte pool (MGP), half-time disappearance (T1/2) and granulocyte turnover rate (GTR)

Range Table - link
Organism Human Homo sapiens
Reference Athens JW, Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J Clin Invest. 1961 Jun40 :989-95. p.991 table IVPubMed ID13684958
Method P.989 left column top paragraph:"When granulocytes are labeled with diisopropyl-fluorophosphates (DFP32) and then returned to the circulation of the donor, the labeled granulocytes are distributed in a pool of cells which is approximately two times larger than that calculated from the blood volume and the concentration of granulocytes in the circulating venous blood (refs 1, 2)."
Comments P.991 left column 2nd paragraph:"Since exercise did not influence the slope of the disappearance curve, the GTR was calculated for each of the subjects. The data are summarized in Table IV. The values for the T1/2 and for the GTR were within normal limits." P.991 left column bottom paragraph:"To determine if epinephrine influences the rate of disappearance of granulocytes from the blood, four subjects were given an infusion of autogenous, DFP32-labeled blood to which 0.5 mg of epinephrine was added. The pool sizes and the T1/2 were then determined. The T1/2 and the GTR were within the normal limits in all four subjects (Table IV)."
Entered by Uri M
ID 112324