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Total iron load

Range	red blood cell ~20: neuron 1 mM
Organism	Mammals
Reference	Theillet FX et al., Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev. 2014 Jul 9 114(13):6661-714. doi: 10.1021/cr400695p p.6663 left column bottom paragraphPubMed ID24901537
Primary Source	[47] McRae R, Bagchi P, Sumalekshmy S, Fahrni CJ. In situ imaging of metals in cells and tissues. Chem Rev. 2009 Oct109(10):4780-827. doi: 10.1021/cr900223a [49] Darbari D et al., Fluorescence measurements of the labile iron pool of sickle erythrocytes. Blood. 2003 Jul 1 102(1):357-64 DOI: 10.1182/blood-2002-03-0914 [50] Fiedler et al., Intracellular iron concentration of neurons with and without perineuronal nets. Nuclear Instruments & Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms (2007), 260 (1), 153-158PubMed ID19772288, 12623854
Comments	P.6663 left column bottom paragraph: "Specialization and metabolic activities further modulate intracellular metal concentrations. The total iron load in red blood cells is ∼20 mM for example, while it is 1 mM in neurons (primary sources)." Please note: primary sources [47] and [49] seem to have studied humans and primary source [50] seems to have studied rats.
Entered by	Uri M
ID	115790