Number of lactate dehydrogenase (LDH) molecules

Range beginning of growth 203 copies/cell: after 4 days of growth >1,000 copies/cell
Organism Bacteria Mycoplasma pneumoniae
Reference Wodke JA et al., Dissecting the energy metabolism in Mycoplasma pneumoniae through genome-scale metabolic modeling. Mol Syst Biol. 2013 9: 653. doi: 10.1038/msb.2013.6 p.5 left column 2nd paragraphPubMed ID23549481
Primary Source Maier T et al., (2011) Quantification of mRNA and protein and integration with protein turnover in a bacterium. Mol Syst Biol 7: 511 doi: 10.1038/msb.2011.38PubMed ID21772259
Comments P.5 left column 2nd paragraph: "A shift from energetically favorable acetic acid production during early growth (4 ATP/glucose) toward predominantly lactic acid production during later growth stages (two ATP/glucose) has been observed (Supplementary Figure S5C–E). Concurrently, cellular lactate dehydrogenase levels (MPN674, LDH) increased five‐fold from 203 copies to above 1000 copies per cell during 4 days of growth (primary source)."
Entered by Uri M
ID 115486