| Range |
<6–8 months
|
| Organism |
Mouse Mus musculus |
| Reference |
Langlais D, Couture C, Kmita M, Drouin J. Adult pituitary cell maintenance: lineage-specific contribution of self-duplication. Mol Endocrinol. 2013 Jul27(7):1103-12. doi: 10.1210/me.2012-1407 p.1110 right column top paragraphPubMed ID23754801
|
| Method |
Abstract: "[Investigators] have used a genetic trick that eliminates dividing cells by apoptosis in order to assess the contribution of differentiated corticotropes and melanotropes for maintenance of their population in the adult pituitary. The system relies on chromosome instability created by the action of the Cre recombinase on inverted loxP sites." |
| Comments |
P.1110 left column bottom paragraph: "Collectively, these data indicate that maintenance of POMC [proopiomelanocorti] cells is very different in AL [anterior lobe] and IL [intermediate lobe], with self-duplication of differentiated corticotropes representing the major mechanism for maintenance of this pool in adult tissues. Interestingly, the slow depletion of about 55% of corticotropes observed over 8.5 months in invloxP/+:POMC-Cre mice is similar to the penetrance of the POMC-Cre transgene (Figure 2B): this may be taken to indicate that the lifespan of corticotropes does not extend beyond 6–8 months and hence that all corticotropes would have been lost by 8 months if the POMC-Cre transgene was fully penetrant. This is also consistent with the absence of further corticotrope loss up to 2 years of age." |
| Entered by |
Uri M |
| ID |
115282 |