| Range |
in mitochondria 3µm: in blood plasma 5.5µm: in erythrocyte 0.5µm µm
|
| Organism |
Human Homo sapiens |
| Reference |
Ferrer-Sueta G, Radi R. Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. ACS Chem Biol. 2009 Mar 20 4(3):161-77. doi: 10.1021/cb800279q p.170 box 1 top paragraphPubMed ID19267456
|
| Primary Source |
[62] Romero N, Denicola A, Souza JM, Radi R. Diffusion of peroxynitrite in the presence of carbon dioxide. Arch Biochem Biophys. 1999 Aug 1 368(1):23-30 DOI: 10.1006/abbi.1999.1272PubMed ID10415107
|
| Comments |
P.170 box 1 top paragraph: "Box 1. Diffusion as a kinetic contender: Diffusion across membranes can constitute an important kinetic determinant in peroxynitrite fate (refs 10, 30, 61-63). First, the half-life of peroxynitrite consumption limits the distance a molecule can travel before decaying by chemical reaction. Using the values in Figure 2 to estimate half-lives and Fick’s second law, it can be determined that peroxynitrite can traverse a mean distance of 3, 5.5, and 0.5 μm in mitochondria, blood plasma, and erythrocytes, respectively, during one-half-life. These numbers indicate that peroxynitrite formed in plasma is very likely to encounter an erythrocyte before decaying (primary source)." |
| Entered by |
Uri M |
| ID |
115228 |