Fraction of cells in the CNS (central nervous system) that are microglia

Value 10 %
Organism Unspecified
Reference Aguzzi A, Barres BA, Bennett ML. Microglia: scapegoat, saboteur, or something else? Science. 2013 Jan 11 339(6116):156-61. doi: 10.1126/science.1227901 p.156 middle column bottom paragraphPubMed ID23307732
Comments P.156 middle column bottom paragraph: "Microglia are parenchymal tissue macrophages with delicate branching processes (“ramified,” or treelike) that include 10% of cells in the CNS. Unlike CNS macrophages found in the meninges, choroid plexus, and perivascular space, microglia derive from macrophages produced by primitive hematopoiesis in the yolk sac (ref 5)." See Benarroch 2013 PMID 23946308 p.1079 left column top paragraph: "Microglial cells are the immune cells in the CNS and represent approximately 10% of the total brain cell population." See Wen et al. 2011 PMID 21783017 p.488 left column: "Microglial cells originate from bone-marrow derived monocytes migrating to the central nervous system during the perinatal period, and they account for 5–12% of the total cells in the central nervous system."
Entered by Uri M
ID 114500