Speed of high mobility chromosome regions

Range 0.1 - 0.5 µm/sec
Organism Eukaryotes
Reference Vuković LD, Jevtić P, Edens LJ, Levy DL. New Insights into Mechanisms and Functions of Nuclear Size Regulation. Int Rev Cell Mol Biol. 2016 322:1-59. doi: 10.1016/bs.ircmb.2015.11.001 p.33 bottom paragraphPubMed ID26940517
Primary Source K. Bystricky, T. Laroche, G. van Houwe, M. Blaszczyk, S.M. Gasser Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization J. Cell Biol., 168 (2005), pp. 375-387 DOI: 10.1083/jcb.200409091 AND J.R. Chubb, W.A. Bickmore, Considering nuclear compartmentalization in the light of nuclear dynamics, Cell, 112 (2003), pp. 403-406PubMed ID15684028, 12600306
Comments P.33 bottom paragraph: "Chromosome positioning is not random within the three-dimensional volume of the nucleus. Rather, chromosomes occupy specific positions, called chromosome territories (Cremer and Cremer, 2010). Chromosomal movements are generally limited to short distances (Marshall et al., 1997), although some genes can change their position within the nucleus from the periphery to the center without large-scale changes in chromosome positioning (Albiez et al., 2006, Misteli, 2007). Long distance chromosome movements are rare and are usually observed during cell differentiation or transformation (Zink et al., 1998). High mobility chromosome regions can move at 0.1–0.5 μm/s (primary sources)." 1st primary source studied budding yeast
Entered by Uri M
ID 114006