| Range |
0.1-0.2 mutation/genome/generation
|
| Organism |
Virus |
| Reference |
Duffy S, Shackelton LA, Holmes EC. Rates of evolutionary change in viruses: patterns and determinants. Nat Rev Genet. 2008 Apr9(4):267-76 p.268 right column top paragraphPubMed ID18319742
|
| Primary Source |
[2] Drake, J. W., Charlesworth, B., Charlesworth, D. & Crow, J. F. Rates of spontaneous mutation. Genetics. 148, 1667–1686 (1998). [10] Drake, J. W. Rates of spontaneous mutation among RNA viruses. Proc. Natl Acad. Sci. USA 90, 4171–4175 (1993).PubMed ID9560386, 8387212
|
| Comments |
P.268 right column top paragraph: "Finally, the fidelity of RTs [reverse transcriptases] is higher than that of RdRps [RNA-dependent RNA polymerases](although it is still lower than that of DNA polymerases), resulting in lower mutation rates in retroviruses than in RNA viruses. For example, when not integrated into host genomes, rates of 0.1–0.2 mutations per genome, per generation have been estimated for viruses like the human immunodeficiency virus type-1 (HIV-1) and hepatitis B virus (HBV)[primary sources], a rate that is approximately fivefold lower than observed in some viruses that replicate using RdRps [primary source 10]. Hence, the rapid evolutionary dynamics that are exhibited by HIV-1 also reflect high rates of recombination [ref 15] and frequent positive selection [ref 16]." |
| Entered by |
Uri M |
| ID |
112771 |