EGFR (epidermal growth factor receptor) levels (see comments section for normal cell types)

Range normal cells 5,000 to 200,000: cancer cells ≤2––3×10^6 EGFR/cell
Organism Mammals
Reference Sorkin A, Duex JE. Quantitative analysis of endocytosis and turnover of epidermal growth factor (EGF) and EGF receptor. Curr Protoc Cell Biol. 2010 MarChapter 15:Unit 15.14. doi: 10.1002/0471143030.cb1514s46. p.17 right column top paragraphPubMed ID20235100
Comments P.17 right column top paragraph: "Critical Parameters and Troubleshooting: Consideration of EGFR expression levels—The design and interpretation of the quantitative analysis of EGFR turnover and trafficking must take into consideration the expression levels of EGFR in the cell line to be studied. Normal mammalian cells express from 5,000 (most epithelial and fibroblast cells) to 200,000 (hepatocytes) EGFR per cell. Cancer cells express up to 2–3 × 10^6 EGFR/cell. Recombinant EGFR can be stably expressed in cells at different levels to directly analyze the dependency of the parameters of the EGFR biosynthesis, endocytosis, recycling, and degradation on the EGFR concentration in the cell."
Entered by Uri M
ID 112720