BioNumber Details Page

Click search to return to the full list.
ID112335
Property Turnover rate for the replacement of the entire epithelium
Organism Metazoa animals
Range 3 - 4
Units days
Reference Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992 Nov119(3):493-501. p.499 left column
Reference PubMed ID 1400587
Primary Source Wright, N., and M. Alison. 1984. The Biology of Epithelial Cell Populations. Clarendon Press, Oxford. 537-891 and 981-1004.
Method pulse-chase experiments
Comments P.499 left column:"[Investigators'] prime objective in this work was to correlate the pattern of TUNEL [the method of TdT-mediated dUTP-biotin nick end labeling, see Method section in BNID 112334] staining in situ with data about systems in which PCD [programmed cell death] existence was already suspected through other means. The small intestine epithelium is typified by a high turnover rate (3-4 d for the replacement of the entire epithelium) and well-defined architecture of repetitive proliferating units where the location of cells which are about to be disposed, is known through pulse-chase experiments (summarized by primary source)."
Entered By Uri M
Date Added Dec 30, 2015 11:53 AM
Date Edited Dec 30, 2015 12:27 PM
Version 5
Permalink http://bionumbers.hms.harvard.edu//bionumber.aspx?id=112335&ver=5
login to add BioNumbers

Post Your Comment
Comments

Retype the characters from the picture:
Related BioNumbers:
  Half life of ubiquitin
Chinese hamster ovary (CHO)
9 Hours
  Half life of AraC protein in vivo
Bacteria Escherichia coli
60 min
  Total (free and bound) lipoproteins per cell
Bacteria Escherichia coli
300000 Molecules/cell