Turnover time of Paneth cells

Range ~15 days
Organism Mouse Mus musculus
Reference Karam SM, Lineage commitment and maturation of epithelial cells in the gut. Front Biosci. 1999 Mar 15 4: D286-98. p.286 right column top paragraph & p.293 right column 4th paragraphPubMed ID10077541
Primary Source [64] H. Cheng: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am J Anat 141, 521-36 (1974)PubMed ID4440634
Comments P.286 right column top paragraph:"In the crypt-villus units of the small intestine, while both absorptive and goblet cells migrate outwards and for each the turnover time is about 3 days, Paneth cells migrate inwards and their turnover time is about 15 days." p.293 right column 4th paragraph:"Paneth cells along the crypt base can not divide by mitosis. Thus, they are only developed from maturation of the stem cells (primary source 64, ref 65). With time, Paneth cells migrate inward to the crypt bottom. The overall turnover time of Paneth cells is about 15 days (primary source 64)."
Entered by Uri M
ID 112306