Neutrophil speed

Value 17 µm/min Range: ±6 µm/min
Organism Human Homo sapiens
Reference Butler KL et al., Burn injury reduces neutrophil directional migration speed in microfluidic devices. PLoS One. 2010 Jul 30 5(7):e11921. doi: 10.1371/journal.pone.0011921. p.5 right columnPubMed ID20689600
Method Abstract:"...[investigators] developed a microfluidic device that is simple to operate and allows for precise and robust measurements of chemotaxis speed and persistence characteristics at single-cell resolution. Using this assay, [they] established a reference set of migration speed values for neutrophils from healthy subjects."
Comments P.5 left column:"In additional control experiments, in the absence of fMLP [N-Formylmethionyl-leucyl-phenylalanine] chemokine, neutrophils did not migrate through the side channels of the device. Furthermore, when a sample of neutrophils was diluted ten-fold, the measured average migration speed was unchanged (17±6 µm/min and 18±4 µm/min, p = 0.3), suggesting that migration speed was independent of the concentration of neutrophils in the device."
Entered by Uri M
ID 112247