Mean inter-ORI [origin of replication] intervals

Range yeast species ~30 - 50kb: Drosophila melanogaster 27kb: mammals ~40kb: Arabidopsis 77kb kb
Organism Eukaryotes
Reference Michael Lynch and Georgi K. Marinov, The bioenergetic costs of a gene, PNAS 2015 doi: 10.1073/pnas.1514974112 link Supplementary Materials p.1 right column bottom paragraph
Primary Source [15] Di Rienzi SC, Lindstrom KC, Mann T, Noble WS, Raghuraman MK, Brewer BJ. 2012. Maintaining replication origins in the face of genomic change. Genome Res 22(10):1940-1952. doi: 10.1101/gr.138248.112. [16] McGuffee SR, Smith DJ, Whitehouse I. 2013. Quantitative, genome-wide analysis of eukaryotic replication initiation and termination. Mol Cell 50(1):123-135. doi: 10.1016/j.molcel.2013.03.004. [17] Eaton ML, Prinz JA, MacAlpine HK, Tretyakov G, Kharchenko PV, MacAlpine DM. 2011. Chromatin signatures of the Drosophila replication program. Genome Res 21(2):164-174. doi: 10.1101/gr.116038.110. [18] Cadoret JC, Prioleau MN. 2010. Genome-wide approaches to determining origin distribution. Chro- mosome Res 18(1):79-89. doi: 10.1007/s10577-009-9094-2. [19] Costas C et al., 2011. Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks. Nat Struct Mol Biol 18(3):395-400. doi: 10.1038/nsmb.1988.PubMed ID22665441, 23562327, 21177973, 19921448, 21297636
Comments Supplementary Materials p.1 right column bottom paragraph:"Large numbers of ORIs occupy eukaryotic chromosomes, with mean inter-ORI intervals being on the order of 30 to 50kb in yeast species [primary sources 15, 16], 27 kb in Drosophila melanogaster [primary source 17], ~40 kb in mammals [primary source 18], and 77 kb in Arabidopsis [primary source 19]."
Entered by Uri M
ID 112141