Fraction of minimal theoretical ATP requirement consumed by translation

Range >70 %
Organism Unspecified
Reference Pontes MH, Sevostyanova A, Groisman EA. When Too Much ATP Is Bad for Protein Synthesis. J Mol Biol. 2015 Aug 14 427(16):2586-94. doi: 10.1016/j.jmb.2015.06.021 p.2587 left column top paragraphPubMed ID26150063
Primary Source Stouthamer AH. A theoretical study on the amount of ATP required for synthesis of microbial cell material. Antonie Van Leeuwenhoek. 1973 39(3):545-65PubMed ID4148026
Comments The actual consumption is much higher and thus the fraction explained by translation is smaller. p.2586 right column bottom paragraph:"Proteins carry out the vast majority of the biochemical activities in living cells. Despite the increased appreciation of RNA's enzymatic and regulatory abilities [ref 10], proteins are largely responsible for the structural, transport and catalytic properties of all cells [ref 1]. Consuming over 70% of the ATP pools utilized by biosynthetic processes, translation is the most expensive anabolic activity [primary source]." See BNID 104849
Entered by Uri M
ID 111918