ATP consumption per action potential

Value 600 10e6 ATP molecules Range: 480-800 10e6 ATP molecules
Organism Rat Rattus norvegicus
Reference Hallermann, S., de Kock, C.P.J., Stuart, G.J., and Kole, M.H.P. (2012). State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci. 2012 Jun 3 15(7):1007-14. doi: 10.1038/nn.3132. range given in p.1007 right column 2nd paragraph & p.1013 right column top paragraphPubMed ID22660478
Method Modeling of L5 cortical neurons in the Rat based on measurements from male Wistar rats (3–5 weeks of age) acute slice preparations. "Using an in vivo–labeled and fully reconstructed thick-tufted cortical L5 pyramidal neuron, [investigators] estimated that action potential propagation into the dendrites and the axon consumed ~90% of the total action potential energy budget. In terms of ATP consumption, the total cost per action potential was observed to range from ~480 to ~800×10^6 ATP molecules, depending on cell morphology. Finally, [they] found that excess axonal Na+ influx was critical for action potential conduction at high frequencies, revealing a trade-off between energy minimization and conduction reliability."
Comments "Using models of L5 pyramidal neurons from in vivo recordings, containing the complete three-dimensional axonal and dendritic tree, [investigators] directly calculated that the total quantity of ATP molecules required to restore the Na+ and K+ gradient after one action potential is between ~480 and ~800 × 10^6 ATP molecules for average thick- and slender-tufted L5 neurons, respectively (Fig. 6)." Note-value of 6E+8ATP not found in text
Entered by Boaz Mohar
ID 111183