Axonal action potential properties from recent studies of cell types in three major brain regions

Range Table - link
Organism Mammals
Reference Kress GJ, Mennerick S. Action potential initiation and propagation: upstream influences on neurotransmission. Neuroscience. 2009 Jan 12 158(1):211-22. doi: 10.1016/j.neuroscience.2008.03.021. p.217 table 1PubMed ID18472347
Primary Source See pointers to refs in 'Reference' column on right of table
Method See 'Recording configuration' column
Comments "The most direct measurements of action potential latencies and conduction velocities come from dual somatic and axonal intracellular recordings. Because of the small size of most CNS glutamatergic axons, such intracellular recordings have been possible only in the axon initial segment region or in distal axon by recording from axon “blebs,” the balled ends of axons created by the slicing procedure. These recordings have allowed direct identification of the arrival/development of the action potential peak in the soma and at various points along the axon of layer 5 neocortical neurons. The recordings thus predict conduction velocities, measured as the arrival of the action potential peak, that are slower in the antidromic direction than in the orthodromic direction (Shu et al., 2006, 2007a,b Kole et al., 2007) (Table 1). The recordings also verify axonal initiation, showing that the action potential normally develops first in the initial segment of the axon (Shu et al., 2007b Schmidt-Hieber et al., 2008)...The propagation time for an action potential traveling from the axonal action potential initiation site to a presynaptic bouton could be up to several milliseconds for both myelinated and unmyelinated axons. Table 1 shows the orthodromic conduction velocities for a variety of neurons studied with recent single-fiber techniques."
Entered by Uri M
ID 111176