Critical threshold concentration of glucose in liver
Range | ~6 mM |
---|---|
Organism | Human Homo sapiens |
Reference | Konig M, Bulik S, Holzhütter HG. 2012. Quantifying the contribution of the liver to glucose homeostasis: a detailed kinetic model of human hepatic glucose metabolism. PLOS Computational Biology 8:e1002577. doi:10.1371/journal.pcbi.1002577. p.1 left column bottom paragraphPubMed ID22761565 |
Comments | "The liver is a central player in buffering plasma glucose contributing either by net hepatic glucose utilization (HGU) or net hepatic glucose production (HGP) depending on the plasma glucose level exceeding or falling below a critical threshold value (in the following referred to as ‘set point’) of ~6 mM. Switching between HGP and HGU is therefore a switch between positive (i.e. export of glucose) and negative (i.e. import of glucose) net hepatic glucose balance." |
Entered by | Uri M |
ID | 110777 |