| Range |
oxidation of glutamine 60, oxidation of glucose 30, oxidation of acetyl-CoA 10 %
|
| Organism |
Mammalian tissue culture cell |
| Reference |
Fan J, Kamphorst JJ, Mathew R, Chung MK, White E, Shlomi T, Rabinowitz JD. Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia. Mol Syst Biol. 2013 Dec 3 9: 712. doi: 10.1038/msb.2013.65. p.3 right columnPubMed ID24301801
|
| Method |
"To study ATP production routes, [researchers] used Bax-/-, Bak-/-
murine renal epithelial cells immortalized by expression of
adenovirus E1A and dominant-negative p53 (Degenhardt et al,
2002) (iBMK cells)." |
| Comments |
"Tracking the source of reducing power, [researchers] found that
oxidation of glutamine, glucose, and acetyl-CoA derived from
other sources (such as unlabeled fatty acids or amino acids)
contributes 60, 30, and 10% of the total NADH/FADH2
production, respectively." iBMK=Immortalized baby mouse kidney epithelial cells |
| Entered by |
Uri M |
| ID |
110685 |