Production rate of IgM producing plasma cells

Value 273 pg of antibody/cell/24 h
Organism Human Homo sapiens
Reference Bromage E, Stephens R, Hassoun L. The third dimension of ELISPOTs: quantifying antibody secretion from individual plasma cells. J Immunol Methods. 2009 Jul 31 346(1-2):75-9. doi: 10.1016/j.jim.2009.05.005. link p.78 right column top paragraph PubMed ID19465022
Primary Source Werner-Favre, C., Matthes, T., Barnet, M., Zubler, R.H.,1993. High IgE secretion capacity of human plasma cells. Eur. J. Immunol. 23, 2038.PubMed ID8344372
Method P.78 left column bottom paragraph"[Primary source researchers] examined individual cells via limiting dilution analysis and quantitative ELISA to approximate the secretion of IgM, IgG, IgA, and IgE from precursors over a 3 day period (primary source). Utilizing these techniques, they estimated that IgM producing plasma cells were producing 273 pg of antibody/cell/24 h."
Entered by Uri M
ID 110220