Lifetime of IL-4 m-RNA in Th2 cells
| Range | ~90 Minutes |
|---|---|
| Organism | Mouse Mus musculus |
| Reference | Mariani, L., Schulz, E. G., Lexberg, M. H., Helmstetter, C., Radbruch, A., Löhning, M., & Höfer, T. (2010). Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression. Molecular systems biology, 6(1). p.3 right column bottom paragraphPubMed ID20393579 |
| Method | Abstract: "Here, [researchers] study the interleukin-4 gene (il4) in T-helper lymphocytes, combining mathematical modeling with the experimental quantification of expression variability and critical parameters." |
| Comments | P.3 right column bottom paragraph: "From the expression kinetics (Figure 1B), [Researchers] found the lifetimes of IL-4 mRNA and intracellular protein to be ~90min (tR) and ~45min (tP), respectively (Supplementary Figure S3), which is in agreement with an earlier report (Yarovinsky et al, 2006)." |
| Entered by | mar.esther23 |
| ID | 110172 |