| Range |
~five months post conception-several million: menopause ~1,000 link - link non growing follicles
|
| Organism |
Human Homo sapiens |
| Reference |
Wallace WH, Kelsey TW. Human ovarian reserve from conception to the menopause. PLoS One. 2010 Jan 27 5(1):e8772. doi: 10.1371/journal.pone.0008772. p.4 fig.4PubMed ID20111701
|
| Primary Source |
Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF (1992) Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Human Reproduction 7: 1342–1346. & Faddy MJ, Gosden RG (1996) A model conforming the decline in follicle numbers to the age of menopause in women. Human Reproduction 11: 1484–1486.PubMed ID1291557, 8671489
|
| Method |
"[Researchers'] model matches the log-adjusted NGF population from conception to menopause to a five-parameter asymmetric double Gaussian cumulative (ADC) curve (r2 = 0.81)." |
| Comments |
"[Researchers'] current understanding of human ovarian reserve presumes
that the ovary establishes several million non growing follicles
(NGFs) at around five months of gestational age which is followed
by a decline to the menopause when approximately 1,000 remain
at an average age of 50–51 years [primary sources]." |
| Entered by |
Uri M |
| ID |
110109 |