Exclusion of glycine-betaine from the Glutamine side chain

Value 7.6 cal/mol
Organism bacteria
Reference Borwankar T, Röthlein C, Zhang G, Techen A, Dosche C, Ignatova Z. Natural osmolytes remodel the aggregation pathway of mutant huntingtin exon 1. Biochemistry. 2011 Mar 29 50(12):2048-60. doi: 10.1021/bi1018368. p.2057 left column bottom paragraphPubMed ID21332223
Comments "GB, however, favored formation of fibrillar aggregates whose phenotype can be explained with the variations in the transfer free energies of Gln side chains: GB is very mildly excluded from the Gln side chain (7.6 cal/mol), indicating little to no changes of Gln solvation by water or by GB."
Entered by Uri M
ID 109636