Number of iron atoms per ferritin (dimer)

Range ≤4,500 Iron atoms/ferritin
Organism Unspecified
Reference Weinberg ED. Cellular regulation of iron assimilation. Q Rev Biol. 1989 Sep64(3):261-90. p.280 right column 3rd paragraphPubMed ID2530602
Method Massover (1993, p.417, 3rd paragraph) states: “Each molecule of ferritin can hold up to 4500 atoms of Iron. This very frequent statement is based upon older measurements of the amount of iron within a given number of molecules. It ignores the results of one experimental study showing that most ferritin used for these measurements was in the form of molecular dimers (Nntsu et al, 1985). Thus, about 2250 and not 4500, atoms of iron is the actual maximum iron content per molecule of horse spleen ferritin.”
Comments "Although each ferritin molecule can accommodate up to 4500 atoms of iron, molecules with 1200 to 1400 atoms are most efficient in facilitating further rapid accumulation as well as prompt release when the metal is required for any of its many useful activities."
Entered by Uri M
ID 108823