The sum of energy expended per vesicle of glutamate released

Value 164000 ATP/vesicle released
Organism Eukaryotes
Reference Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 2001 Oct21(10):1133-45. p.1138 right column 2nd paragraphPubMed ID11598490
Method "To calculate the energy needs of various components of signaling in the brain, [researchers] analyze the transmitter release triggered by a single action potential passing through a typical neuron."
Comments "Summing these estimates for presynaptic Ca2+ entry, vesicle cycling, postsynaptic actions, and glutamate recycling, the energy expended per vesicle of glutamate released is 1.64×10^5 ATP molecules."
Entered by Uri M
ID 108667