Influx of Ca2+ triggerred by presynaptic action potential

Value 12000 Ca2+/vesicle released
Organism Rat Rattus norvegicus
Reference Attwell D, Laughlin SB. An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab. 2001 Oct21(10):1133-45. p.1136 left column 3rd paragraphPubMed ID11598490
Primary Source Helmchen F, Borst JG, Sakmann B. Calcium dynamics associated with a single action potential in a CNS presynaptic terminal. Biophys J. 1997 Mar72(3):1458-71.PubMed ID9138591
Comments "The presynaptic action potential triggers an influx of 1.2×10^4 Ca2+ per vesicle released (at 35°C at calyx synapses (primary source)). This will be extruded by 3 Na+/Ca2+ exchange, requiring 1.2×10^4 ATPs."
Entered by Uri M
ID 108626