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Duration of average splicing event

Value	30 sec
Organism	Various
Reference	Hnilicová J, Stanek D. Where splicing joins chromatin. Nucleus. 2011 May-Jun2(3):182-8. doi: 10.4161/nucl.2.3.15876. p.183 left column 2nd paragraph
Primary Source	Lacadie SA, Tardiff DF, Kadener S, Rosbash M. In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. Genes Dev 2006 20: 2055-66. AND Alexander RD, Barrass JD, Dichtl B, Kos M, Obtulowicz T, Robert MC, et al. RiboSys, a highresolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3'-end processing in Saccharomyces cerevisiae. RNA 2010 16: 2570-80. AND Huranová M et al., The differential interaction of snRNPs with pre-mRNA reveals splicing kinetics in living cells. J Cell Biol. 2010 Oct 4 191(1):75-86. p.83 left column 3rd paragraph AND Wetterberg I, Zhao J, Masich S, Wieslander L, Skoglund U. In situ transcription and splicing in the Balbiani ring 3 gene. EMBO J 2001 20: 2564-74.PubMed ID16882983, 20974745, 20921136, 11350946
Comments	"An average splicing event takes 30 seconds to accomplish (primary sources) and therefore it is very likely that recognition of splice sites as well as intron excision occur when pre-mRNA is still in close proximity to the chromatin of its own gene, and this makes it possible for chromatin modifications to influence splicing."
Entered by	Uri M
ID	108453