Diffusion coefficient of p53 on elongated DNA

Range 3.01х10^5 Table - link nm^2/sec
Organism Human Homo sapiens
Reference DeSantis MC, Li JL, Wang YM. Protein sliding and hopping kinetics on DNA. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Feb83(2 Pt 1):021907 p.3 table 1PubMed ID21405863
Primary Source Tafvizi A, Huang F, Leith JS, Fersht AR, Mirny LA, van Oijen AM. Tumor suppressor p53 slides on DNA with low friction and high stability. Biophys J. 2008 Jul95(1):L01-3
Method Primary source p.L01 right column bottom paragraph: "[Investigators] fluorescently labeled full-length, human p53 and used total internal reflection fluorescence microscopy to visualize its movement along individual λ-phage DNA molecules (Fig. 1, A–D, and see Supplementary Material, Data S1)."
Comments
Entered by Uri M
ID 107462