Electrophysiological properties of two types of EGFP-positive neurons in the striatum

Range Table - link
Organism Mouse Mus musculus
Reference Masuda M et al., Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum. Eur J Neurosci. 2011 Nov34(9):1355-67. doi: 10.1111/j.1460-9568.2011.07873.x. p.1362 table 1PubMed ID22004548
Method "The EGFP-TH+ neurons were recorded in whole-cell, current-clamp mode. All neurons sampled had resting membrane potentials more negative than -55 mV and overshooting spikes. Based on passive and active intrinsic properties revealed by intracellular current injection, these neurons were tentatively classified into two subtypes, EGFP-TH+ Type A and Type B (Fig. 5A and B and Table 1)."
Comments "Spontaneous spike discharge was observed in both types of neurons several minutes after breakage of patch membranes (Type A, 12.9%, 9/70: Type B, 75.0%, 12/16). The resting membrane potential of EGFP-TH+ Type A neurons was -76.0 ± 0.9 mV (n= 131) and the input resistance was 406.0 ± 22.0 M?, whereas EGFP-TH+ Type B neurons had a more depolarized resting membrane potential (-65.3 ± 0.8 mV, n= 37) and a higher input resistance (635.0 ± 54.0 M?) (Table 1, Fig. 5D)."
Entered by Uri M
ID 106956