Number of p53 transcription factor molecules per cell
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| Range | 21,000 LB19 B-lymphoblastoid cell line: 160,000 MCF-7 breast carcinoma cell line Molecules/cell |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Mark D. Biggin, Animal Transcription Networks as Highly Connected, Quantitative Continua, Developmental cell Volume 21, Issue 4, 18 October 2011, Pages 611-626 DOI 10.1016/j.devcel.2011.09.008 p.617 table 1 Table - link PubMed ID22014521 |
| Primary Source | Ma L, Wagner J, Rice JJ, Hu W, Levine AJ, Stolovitzky GA. A plausible model for the digital response of p53 to DNA damage. Proc Natl Acad Sci U S A. 2005 Oct 4 102(40):14266-71.PubMed ID16186499 |
| Method | (Primary source abstract:) Researchers present a model in which double-strand break (DSB) sites induced by ionizing radiation (IR) interact with a limiting pool of DNA repair proteins, forming DSB-protein complexes at DNA damage foci. |
| Comments | See BNID 100420 |
| Entered by | Uri M |
| ID | 106910 |