Diffusion constant of p53

Value 41.6 µm^2/sec Range: ±13.6 Table - link µm^2/sec
Organism Mammalian tissue culture cell
Reference Hinow P, Rogers CE, Barbieri CE, Pietenpol JA, Kenworthy AK, DiBenedetto E. The DNA binding activity of p53 displays reaction-diffusion kinetics. Biophys J. 2006 Jul 1 91(1):330-42 p.338 table 1PubMed ID16603489
Method Abstract: "In this study, [investigators] investigated the intracellular diffusion of a p53-GFP fusion protein using confocal fluorescence recovery after photobleaching [FRAP]. [They] show that the diffusion of p53-GFP within the nucleus is well described by a mathematical model for diffusion of particles that bind temporarily to a spatially homogeneous immobile structure with binding and release rates k1 and k2, respectively."
Entered by Uri M
ID 106693