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|Range||10^-3 to 10^-5 Mutations/site/replication|
|Reference||Domingo E, Holland JJ. RNA virus mutations and fitness for survival. Annu Rev Microbiol. 1997 51: 151-78. p.154 2nd paragraphPubMed ID9343347|
|Comments||Perhaps the feature that most distinguishes RNA genetic elements from cellular DNA is the high mutation rate operating during genome replication. Misinsertion errors during RNA replication and retrotranscription have been estimated to be in the range of 10^-3 to 10^-5 substitutions per nucleotide and per round of copying. For 10^-4 mutations/site/replication see Mueller 1998 PMID 9420196 p.20 left column 2nd paragraph|
|Entered by||Uri M|