Daily turnover of ATP

Value ~1 Body weight ATP/day Range: or ~60kg Body weight ATP/day
Organism Human Homo sapiens
Reference Buono Michael J. and Kolkhorst Fred W. Estimating ATP resynthesis during a marathon run: a method to introduce metabolism, Adv Physiol Educ 25: 70–71, 2001. article - link p.70 right column top & 2nd paragraphs
Method P.70 middle column 2nd & bottom paragraphs: "With the use of the molar equation for the oxidation of carbohydrate, the amount of ATP resynthesized per mole of glucose is C6H12O6+6O2 → 6CO2+6H2O+36ATP. When the reactants and products are expressed in common metric units and by taking into account molecular weights and volumes per mole of ideal gasses, the equation looks like: 180g glucose+134.4liter O2 → 134.4liter CO2+108g H2O+18.25 kg ATP. Thus 0.136 kg of ATP are resynthesized for each liter of O2 consumed."
Comments P.70 right column top & 2nd paragraphs: "Because 438 liters of O2 were used for the marathon, this means that a staggering 60 kg of ATP were resynthesized by Khonnouchi’s (holder of 1999 world record from the 1999 Chicago Marathon) muscles in slightly over 2 h. After seeing the magnitude of this estimate, most students readily comprehend the problem of attempting to store all the ATP that a human would need for existence. The fact that Khannouchi resynthesized-60 kg of ATP during his race drives home the physiological rationale for using metabolic pathways to resynthesize ATP on a need basis rather than storing it." P.70 right column bottom paragraph: "…an average college student typically consumes 400–500 liters of O2 per day…" Note-a value of 1 body weight equivalent /day of ATP given by Törnroth-Horsefield et al., 2008 p. 19565 1st paragraph PMID 19073922
Entered by Uri M
ID 105606