| Value |
995
Unitless
|
| Organism |
Nematode Caenorhabditis briggsae |
| Reference |
Haerty W, Artieri C, Khezri N, Singh RS, Gupta BP. Comparative analysis of function and interaction of transcription factors in nematodes: extensive conservation of orthology coupled to rapid sequence evolution. BMC Genomics. 2008 Aug 27 9: 399. p.3 table 2PubMed ID18752680
|
| Method |
Researchers identified 988 TF genes in C. elegans, and inferred corresponding sets in C. briggsae and C. remanei, containing 995 and 1093 TF genes, respectively. Analysis of the three gene sets revealed 652 3-way reciprocal 'best hit' orthologs (nematode TF set), approximately half of which are zinc finger (ZF-C2H2 and ZF-C4/NHR types) and HOX family members. Examination of the TF genes in C. elegans and C. briggsae identified the presence of significant tandem clustering on chromosome V, the majority of which belong to ZF-C4/NHR family. |
| Comments |
The nematode Caenorhabditis elegans serves as a powerful model organism to unravel TF function due to the wealth of available resources and the ease with which it can be reared, maintained, and manipulated in the laboratory [10]. The completion of its genome sequence has aided in the design of large-scale experiments that are beginning to elucidate the complexity of transcriptional regulation and gene interaction networks in multicelllular eukaryotes [11,12]. The recent releases of the genome sequence of two other Caenorhabditid species, C. briggsae [13] and C. remanei [14], provide an excellent opportunity for genome-wide study of the conservation and evolution of transcription factors across nematodes. These three species are estimated to have shared a common ancestor between 20–120 million years ago [13-15] and while they are morphologically similar, studies have shown differences in development and behavior [16].See BNID 105072,105074 |
| Entered by |
Uri M |
| ID |
105073 |