Increase in concentration of CoQ in brain of scrapie prion diseased mouse

Value 2.5 Fold
Organism Mouse Mus musculus
Reference Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. Biochim Biophys Acta. 2004 Jan 281660(1-2):171-99.PubMed ID14757233
Primary Source Guan Z, Söderberg M, Sindelar P, Prusiner SB, Kristensson K, Dallner G. Lipid composition in scrapie-infected mouse brain: prion infection increases the levels of dolichyl phosphate and ubiquinone. J Neurochem. 1996 Jan66(1):277-85PubMed ID8522965
Method reduced and oxidized Q, were quantitated immediately after homogenization of the tissue.
Comments the total amount of reduced Q on tissue-weight basis increased 2.5 times in the terminally ill mice.
Entered by Uri M
ID 103293