Fraction of transgene-expressed epitope-tagged delta-opioid receptor that is destroyed rapidly by proteasomes

Value 60 %
Organism Human Homo sapiens
Reference Yewdell JW, Reits E, Neefjes J. Making sense of mass destruction: quantitating MHC class I antigen presentation. Nat Rev Immunol. 2003 Dec3(12):952-61. DOI: 10.1038/nri1250 p.958 left column bottom paragraphPubMed ID14647477
Primary Source [63] Petaja-Repo, U. E. et al. Newly synthesized human delta-opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. J. Biol. Chem. 276, 4416–4423 (2001) DOI: 10.1074/jbc.M007151200PubMed ID11054417
Method Primary source: Pulse-chase experiments
Comments P.958 left column 3rd paragraph: "Fifty percent of thyrotropin receptor expressed from a transfected gene is destroyed rapidly by proteasomes [BNID 113778], which also destroy 60% of transgene-expressed epitope-tagged delta-opioid receptor [primary source]."
Entered by Uri M
ID 113779