Increase in lipid to protein ratio in cancer cells over hypoxic cells that would generate a large enough electron sink for oxidation of the cancer proteomes
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| Range | ~20 % |
|---|---|
| Organism | Unspecified |
| Reference | Dick JM, Chemical composition and the potential for proteomic transformation in cancer, hypoxia, and hyperosmotic stress. PeerJ. 2017 Jun 6 5: e3421. doi: 10.7717/peerj.3421 abstract, p.17 4th paragraph & p.19 3rd paragraphPubMed ID28603672 |
| Primary Source | Gordon GB, Barcza MA, Bush ME. 1977. Lipid accumulation in hypoxic tissue culture cells. American Journal of Pathology 88(3):663-678 AND Milo R, Phillips R. 2015. Cell biology by the numbers. New York: Garland SciencePubMed ID196505 |
| Method | Abstract: "A redox balance calculation indicates that an increase in the lipid to protein ratio in cancer cells by 20% over hypoxic cells would generate a large enough electron sink for oxidation of the cancer proteomes." |
| Comments | P.17 4th paragraph: "The worked-out calculation is shown in Fig. 4. The lipid:protein ratio in hypoxia is taken from primary source Gordon, Barcza & Bush (1977), and ballpark values for the differences in ZC [average oxidation state of carbon] of proteins in hypoxia and cancer are from the present study. Notably, the lipid:protein weight ratio in hypoxia (0.19) is higher than in normal cells (i.e., 0.15 using data from primary source Gordon, Barcza & Bush, 1977 or 0.16 using data compiled by primary source Milo & Phillips, 2015 for E. coli). The calculation indicates that an increase of the lipid:protein weight ratio in cancer cells by ca. 20% over that in hypoxic normal cells could provide an electron sink that is large enough to take up the electrons released by oxidation of the proteome in hypoxic normal cells to generate that in hypoxic cancer cells. That proteomic transformation is quantified here by an increase of ΔZC from ca. -0.03 to 0.03, both relative to non-hypoxic normal cells (Fig. 4)." P.19 3rd paragraph: "An electron sink associated with a ca. 20% greater lipid to protein ratio in cancer compared to normal hypoxic cells would be sufficient to balance the electrons released by the formation of more oxidized proteins in CRC [colorectal cancer] and pancreatic cancer." |
| Entered by | Walter Larson |
| ID | 113700 |