| Primary Source |
P. Bertone et al., Global identification of human transcribed sequences with genome tiling arrays, Science, 306 (2004), pp. 2242–2246 DOI: 10.1126/science.1103388 AND P. Carninci et al., The transcriptional landscape of the mammalian genome, Science, 309 (2005), pp. 1559–1563 DOI: 10.1126/science.1112014 AND P. Kapranov et al., Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays, Genome Res., 15 (2005), pp. 987–997 DOI: 10.1101/gr.3455305 AND J.L. Rinn et al., The transcriptional activity of human Chromosome 22, Genes Dev., 17 (2003), pp. 529–540 DOI: 10.1101/gad.1055203PubMed ID15539566, 16141072, 15998911, 12600945
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| Comments |
P.1311 left column bottom paragraph: "A distinguishing feature of metazoan genomes is the abundance of noncoding RNA (ncRNAs), which function by means other than directing the production of proteins. In addition to small regulatory RNAs such as miRNAs, recent studies have predicted the existence of long ncRNAs—ranging from 300 nucleotides (nt) to over 10 kb—that are spliced, polyadenylated, and roughly as diverse in a given cell type as protein-coding mRNAs (primary sources). Long ncRNAs may have diverse roles in gene regulation, especially in epigenetic control of chromatin (Bernstein and Allis, 2005)." |