| Value |
60
new mutations/generation
|
| Organism |
Human Homo sapiens |
| Reference |
Kondrashov A. Genetics: The rate of human mutation. Nature. 2012 Aug 23 488(7412):467-8. doi: 10.1038/488467a. p.467 right columnPubMed ID22914161
|
| Primary Source |
Kong et al., Rate of de novo mutations and the importance of father's age to disease risk. Nature. 2012 Aug 23 488(7412):471-5. doi: 10.1038/nature11396.PubMed ID22914163
|
| Method |
Primary source abstract:"[Researchers] conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage." |
| Comments |
"[Primary source researchers] show
that a newborn’s genome sequence contains,
on average, 60 new small-scale mutations, and
that this number depends strongly on the age
of the father at the time of conception. [Their] study is by far the
largest of its kind yet conducted, involving
78 Icelandic parent–offspring trios." |
| Entered by |
Uri M |
| ID |
110293 |