Mutation rate in individual whose sperm was sequenced
Please note: The entry will be shown to all once approved by the database administrator.
Range | 2e-8 to 4e-8 Mutations/site/generation |
---|---|
Organism | Human Homo sapiens |
Reference | Jianbin Wang, H. Christina Fan, Barry Behr and Stephen R. Quake Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm, Cell 150, 402–412, July 20, 2012 p.408 right column bottom paragraphPubMed ID22817899 |
Method | (p.403 left column 2nd paragraph:) "[Researchers] collected a sperm sample from a 40-year-old Caucasian individual (P0) whose genome has been sequenced (Pushkarev et al., 2009), clinically annotated (Ashley et al., 2010), and haplotype phased (Fan et al., 2011)." |
Comments | "P0’s mutation rate (2–4×10^-8) is higher than that obtained from genome-sequenced pedigree data (~1×10^-8) (Conrad et al., 2011), but it is consistent with evolutionary studies, which have revealed ~4–5× more mutations in male than in female, possibly due to the larger number of germline cell divisions in male (Crow, 2000 Makova and Li, 2002)." |
Entered by | Uri M |
ID | 108040 |