Number of germ-line cell divisions per generation

Range Male 62 : Female 25 divisions/generation
Organism Mouse Mus musculus
Reference Drost JB, Lee WR. Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ Mol Mutagen. 1995 25 Suppl 26:48-64. DOI: 10.1002/em.2850250609 abstract, p.54 fig.4 & p.55 fig.5PubMed ID7789362
Method p. 54 left column 2nd paragraph: "Figures 2-7 - link [link shows only fig.4-5] are diagrammatic summaries of the cell divisions and other major events in the male and female germlines of Drosophila melanogaster, Mus musculus, and Homo supiens through a complete generation in both sexes. These are based on data from the scientific literature, using both classical and modern molecular techniques, in the fields of embryology, cell lineage analysis, mosaic studies, stem cell renewal strategies, gametogenesis, and developmental genetics [Drost, 1993]." For formula of timing number of male germline cell lines in higher animals see p. 55 eq. 6
Comments Abstract:"Recent estimates of the number of germ cell divisions per generation are: for humans, 401 (30-year generation) in males and 31 in females, for mice, 62 (9-month generation) in males and 25 in females and for Drosophila melanogaster, 35.5 (18-day generation) in males and 36.5 (25-day generation) in females."
Entered by Uri M
ID 105576