| Range |
Figure link - link
|
| Organism |
Eukaryotes |
| Reference |
Kunkel TA. Evolving views of DNA replication (in)fidelity. Cold Spring Harb Symp Quant Biol. 2009 74: 91-101 p. 93 fig.2PubMed ID19903750
|
| Primary Source |
McCulloch SD, Kunkel TA. The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res. 2008 Jan18(1):148-61.PubMed ID18166979
|
| Comments |
Measurements of the fidelity of DNA synthesis in vitro
by purified DNA polymerases reveal a remarkable variation
in error rates for the two major types of errors that
polymerases generate: single-base-pair substitutions and
single-base deletions (Figure link). These error rates reflect the
contribution of nucleotide selectivity at the polymerase
active site and proofreading by those polymerases harboring
an associated 3' exonuclease. |
| Entered by |
Uri M |
| ID |
105467 |